| Beeren Lisa |
| Email |
l.beeren ucl.ac.uk |
| Gender |
Female |
| Nationality |
Australia |
| Year of birth |
1981 |
| Department |
Physiology |
| University |
University College London |
| Country (of work) |
United Kingdom |
| Simulation Project Title |
Network connectivity and its effect on noise absorption. |
| Type of model |
Abstract neural network model |
| Description |
In a fully connected network, with 50% inhibitory and excitatory cells, a single extra
excitatory spike will be cancelled out and generate no change in the pattern of activity of
the network. I will use a network model of spiking neurons and vary both connectivity and
ratio of excitatory to inhibitory cells, looking for the connectivity level at which an extra
spike will still affect a network spike pattern, and compare it to analytical calculations and
experimental data from recordings in vivo. |
| Why complementary |
Using whole-cell patch clamping in the anesthetised rat, I have recorded changes of neuron
spiking frequency following current injection. I plan to model data from simultaneous extra-
and intra-cellular recording to assess the effect an extra spike has on a network. This will
provide interesting insights into a networks ability to absorb or propagate noise depending on
its connectivity parameter and complement my interest in the value of precise spike patterns
in the transmission of information. |
| Tutor |
Tim Vogels |