| Hoyos Erika |
| Email |
hoyose u.washington.edu |
| Gender |
Female |
| Nationality |
Colombia |
| Year of birth |
1983 |
| Department |
Center for Cell Dynamics |
| University |
University of Washington |
| Country (of work) |
United States Of America |
| Simulation Project Title |
Stabilization of memory by the MAPK pathway. |
| Type of model |
Don't know yet |
| Description |
ERK regulation by Ras/MAPK pathway leads to CREB expression. NMDA and other receptors can
modulate this pathway to cause a prolonged phosphorylation of CREB to induce LTP. This output
alters membrane properties and control NMDA receptor activation. NMDA receptors are 3-way
coincidence detectors: synaptic glutamate, back propagating action potential, a stimulus. I
would like to simulate how ERK activation detects this 3-way coincidence to generate
electrical response, such as LTP. |
| Why complementary |
In the vulva development model, the Ras/MAPK and Notch pathways behave as a tri-stable
switch to determine three different cellular fates. Since the Ras/MAPK pathway plays a pivotal
role in LTP induction and maintenance, I would like to analize how this pathway is capable to
stabilize memory traces within neurons, similarly to cellular fates within precursor
cells. |
| Tutor |
Janet Best |