| Diaz-Quesada Marta |
| Email |
mdiaz umh.es |
| Gender |
Female |
| Nationality |
Spain |
| Year of birth |
1980 |
| Department |
Cellular and Systems Neurobiology |
| University |
Instituto de Neurociencias de Alicante |
| Country (of work) |
Spain |
| Simulation Project Title |
Single-neuron models of adaptive gain rescaling. |
| Type of model |
One-compartmental model single cell |
| Description |
Adaptation of a neurons firing rate often occurs with changes in its stimulus-response
relationship, e.g., tuning curve gain rescaling. Whether adaptation and gain rescaling are
caused by the same mechanisms is often unclear. Rescaling can be an automatic property of
spike generation and can occur in integrate-and-fire neurons. I aim to explore gain modulation
in spiking models and use the results to predict if experimental examples of rescaling are
automatic or need additional mechanisms. |
| Why complementary |
I study how intrinsic mechanisms participate in adaptation in barrel cortex. Using
whole-cell patch recordings in slices, I found that neurons firing rates adapt to changes in
stimulus distribution, a behavior caused by intrinsic properties. This adaptation occurs
together with gain rescaling in the neurons tuning functions. We do not know whether the
phenomena are due to the same mechanisms. This project would give me insight into my
experimental results and help me in future predictions. |
| Tutor |
Janet Best |