| Ostojic Srdjan |
| Email |
srdjan lps.ens.fr |
| Gender |
Male |
| Nationality |
France |
| Year of birth |
1978 |
| Department |
Laboratoire de Physique Statistique |
| University |
Ecole Normale Superieure |
| Country (of work) |
France |
| Simulation Project Title |
Dendritic integration of granular bursts by Purkinje cells. |
| Type of model |
Multi-compartmental model single cell |
| Description |
Purkinje cells provide the only output from the cerebellar cortex. Via their extensive
dendritic tree, these cells integrate excitatory inputs from a large number of granule cells.
It has been recently reported that individual granule cells emit bursts of spikes, and not
only single spikes as believed so far. The aim of my project is to study the effect of these
bursts on the integration properties of Purkinje cells using an available multi-compartmental
model (eg De Schutter & Bower 94). |
| Why complementary |
My present research activity consists in a mathematical analysis of the network activity
in the cerebellum. The individual cells are modelled as single-compartement integrate and fire
neurons. Studying a detailed multi-compartement model of a cerebellar cell will allow me to
assess the validity of our simplified description, and in particular to examine the effect of
dendritic structure and complex spikes on the summation of inputs. |
| Tutor |
Alex Roxin |