| Parameshwaran Dhanya |
| Email |
dhanya ncbs.res.in |
| Gender |
Female |
| Nationality |
India |
| Year of birth |
1983 |
| Department |
Neurobiology |
| University |
National Centre for Biological Sciences, TIFR |
| Country (of work) |
India |
| Simulation Project Title |
Can networks of real computing neurons be programmed? |
| Type of model |
Compartmental model based network model |
| Description |
A network with two inputs, one modulates the firing of output neurons to the other input.
CA1 neurons in the hippocampus have this architecture;receives dual inputs through
SchafferCollaterals(SC) proximally and TemporoAmmonic Pathway(TA) distally. TA input based on
their timing, can either increase or decrease the probability of SC-evoked CA1 spikes. The TA
pathway thus acts like a handle, and theoretically, enables us to store and erase desired
patterns of information or program the network. |
| Why complementary |
Currently, we are using optical recordings to take a parallel readout of the network in
the CA1 region invitro, with only SC inputs. But, with TA inputs as a handle, can we write
desired synaptic matrices into the network? Does the TA input play the role of a buffer; which
can activate/inactivate the response of the CA1 neurons? This will be a logical extension to
my project; additionally, I am equipped with an experimental setup to test the model. |
| Tutor |
Michelle Lilith |