Paper Available: Model of Cortical Layer 4

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The following paper is now available as
ftp://ftp.keck.ucsf.edu/pub/ken/kayser_miller.pdf
or from
http://www.keck.ucsf.edu/~ken (click on 'Publications', then on
                               'Models of Neural Development').

Kayser, A.S. and K.D. Miller. "Opponent inhibition: A developmental
model of layer 4 of the neocortical circuit".
    This is a final draft of a manuscript that has now appeared as
Neuron 33, 131-142 (2002).

Summary:

We model the development of the functional circuit of layer 4, the
input-recipient layer, of cat primary visual cortex. The observed
thalamocortical and intracortical circuitry codevelop under Hebb-like
synaptic plasticity. Hebbian development yields opponent inhibition:
inhibition evoked by stimuli anticorrelated with those that excite a
cell. Strong opponent inhibition enables recognition of stimulus
orientation in a manner invariant to stimulus contrast. These
principles may apply to cortex more generally: Hebb-like plasticity
can guide layer 4 of any piece of cortex to create opposition between
anticorrelated stimulus pairs, and this enables recognition of
specific stimulus patterns in a manner invariant to stimulus
magnitude. Properties that are invariant across a cortical column are
predicted to be those shared by opponent stimulus pairs; this
contrasts with the common idea that a column represents cells
with similar response properties.

Ken
 
        Kenneth D. Miller telephone: (415) 476-8217
        Associate Professor fax: (415) 476-4929
        Dept. of Physiology, UCSF internet: ken@phy.ucsf.edu
        513 Parnassus www: http://www.keck.ucsf.edu/~ken
        San Francisco, CA 94143-0444

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