New Paper

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New Paper:

The Effect of Dendritic Topology on Firing Patterns in Model Neurons

Arjen van Ooyen, Jacob Duijnhouwer, Michiel W. H. Remme & Jaap van Pelt,

Network: Computation in Neural Systems (2002) 13: 311-325.

Please request reprint: A.van.Ooyen@nih.knaw.nl
Or download from Network (as PDF):
http://www.iop.org/EJ/S/UNREG/bVveqqfl6o4Pl9WBtrYaaQ/article/-ffissn=0954-898X/-ff30=all/0954-898X/13/3/304/ne2304.pdf

Abstract

Neuronal firing patterns are influenced by both membrane properties and
dendritic morphology. Distinguishing two sources of
morphological variability---metrics and topology---we investigate the
extent to which model neurons that have the same metrical
and membrane properties can still produce different firing patterns as a
result of differences in dendritic topology. Within a set of
dendritic trees that have the same number of terminal segments and the
same total dendritic length, we show that firing frequency
strongly correlates with topology as expressed by the mean dendritic
path length. The effect of dendritic topology on firing
frequency is bigger for trees with equal segment diameters than for
trees whose segment diameters obey Rall's 3/2 power law. If
active dendritic channels are present, dendritic topology influences not
only firing frequency but also type of firing (regular,
bursting).

--
Arjen van Ooyen, Netherlands Institute for Brain Research,
Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands.
email: A.van.Ooyen@nih.knaw.nl
website: http://www.anc.ed.ac.uk/~arjen
phone: +31.20.5665483  fax: +31.20.6961006

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