Computational Biology of Time

From: Terry Sejnowski (
Date: Fri Oct 25 2002 - 13:28:12 CEST


Organizers: Terrence Sejnowski and Sydney Brenner
January 31 - February 4, 2003

Banff Centre - Banff, Alberta

Abstract Deadline: November 1, 2002
Early Registration Deadline: December 2, 2002

Time is the final frontier in biology and uncovering molecular and cellular
mechanisms in cells that keep time is essential to understanding biological
systems. Biological clocks cover a wide range of time scales, from the
heartbeat to circadian rhythms. In each of these systems, molecular mechanisms
are being uncovered that underlie these rhythms and stabilize them, but the
number of molecules and the complexity of their interactions are daunting.
There is growing interest in applying computational models to these biological
systems. This symposium brings together some of the leading computational model
builders and key researchers studying the circadian clock, photoperiodism in
plants, the cell cycle in yeast, cardiac rhythms, brain rhythms that occur
during sleep and firefly synchronization. The mathematical principles that
emerge from the models highlight deep similarities that exist between these
diverse systems, and allow a broader understanding to emerge for how biological
systems organize time in robust and effective ways.

Friday, January 31, 7:30 - 8:30 PM: Keynote Address:

Sydney Brenner, 2002 Nobel Prize in Physiology or Medicine
                HOW CELLS COMPUTE

Saturday, February 1, 8:00 - 11:00 AM


Joseph S. Takahashi, Northwestern University
"Circadian Clock Genes"

Martha U. Gillette, University of Illinois
"Circadian Pacemaker in the Suprachiasmatic Nucleus?"

Stanislas Leibler, Rockefeller University
"Oscillations and Noise in Genetic Networks"

Albert Goldbeter, Université Libre de Bruxelles
"Computational Biology of Circadian Rhythms"

Saturday, February 1, 5:00 - 7:00 PM


Andrew Moiseff, University of Connecticut
"Temporal Rhythms in Firefly Communication"

Wolfgang O. Friesen, University of Virginia
"Coupled Central and Peripheral Oscillators Generate Efficient
Swim Undulations"

G. Bard Ermentrout, University of Pittsburgh
"Coupled Neural Oscillators"

Sunday, February 2, 8:00 - 11:00 AM


David A. McCormick, Yale University
"Slow Oscillations in Thalamic and Cortical Slices"

Mircea Steriade, Université Laval
"Sleep Oscillations In Vivo"

Terrence Sejnowski, Salk Institute
"Neural Models of Sleep Rhythms"

Alexander A. Borbely, University of Zurich
"Sleep in Humans: Intrinsic and Extrinsic Oscillations"

Sunday, February 2, 5:00 - 7:00 PM


Steve A. Kay, The Scripps Research Institute
"Comparative Genetics and Genomics Approaches to
"Understanding Circadian Clock and Photoperiodism?

Susan S. Golden, Texas A & M University
"Plasticity of circadian rhythms of gene expression in cyanobacteria"

Takao Kondo, Nagoya University
"Genome-Wide Circadian System of Cyanobacteria Driven by Kai
Feedback Loop"

Monday, February 3, 8:00 - 11:00 AM


Denis Noble, University of Oxford
"The Modes of Oscillation of the Heart"

Peter Hunter, University of Auckland
"Electro-Mechanical Heart Model"

John Peter Wikswo Jr. , Vanderbilt University
"Cardiac Reentry as a Spatiotemporal Oscillator"

Leon Glass, McGill University
"Puzzles Concerning the Starting and Stopping of Biological

Monday, February 3, 5:00 - 7:00 PM


John Tyson, Virginia Polytechnic Institute
"Cyberyeast: Modeling the Eukaryotic Cell Cycle"

Marc W. Kirschner, Harvard Medical School
"Modeling the Wnt Signaling Pathway"


For more than 30 years, Keystone Symposia has been connecting the scientific
community in a way no other meeting or conference can. Your opportunity to
enjoy quality scientific discussions, networking among colleagues, and
cutting-edge presentations -- all in a relaxed atmosphere -- is here.
For more information about the Banff Center in Alberta, Canada:


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