Paper on neuronal gain in the leaky integrate-and-fire neuron with conductance synapses



From: Anthony BURKITT (aburkitt@bionicear.org)
Date: Wed Jun 18 2003 - 17:57:27 CEST


The following paper on neuronal gain in the leaky integrate-and-fire
neuron with conductance synapses has been published by Biological
Cybernetics and is now available online:
http://link.springer.de/link/service/journals/00422/first/bibs/s00422-003-0408-8.htm

"Study of neuronal gain in a conductance-based leaky integrate-and-fire
neuron model with balanced excitatory and inhibitory synaptic input"

A. N. Burkitt, H. Meffin, and D. B. Grayden

Abstract:
Neurons receive a continual stream of excitatory and inhibitory synaptic inputs.
A conductance-based neuron model is used to investigate how the balanced component
of this input modulates the amplitude of neuronal responses.
The output spiking-rate is well-described by a formula involving three parameters:
the mean $\mu$ and variance $\sigma$ of the membrane potential and the effective
membrane time constant $\tau_{\mbox{\tiny Q}}$.
This expression shows that, for sufficiently small $\tau_{\mbox{\tiny Q}}$,
the level of balanced excitatory-inhibitory input has a non-linear modulatory
effect on the neuronal gain.

A copy is also available from my web page:
http://www.medoto.unimelb.edu.au/people/burkitta/Burkitt_BC_2003.pdf

Tony Burkitt
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Anthony N. Burkitt
The Bionic Ear Institute
384-388 Albert Street
East Melbourne, VIC 3002
Australia

Email: a.burkitt@medoto.unimelb.edu.au
http://www.medoto.unimelb.edu.au/people/burkitta
Phone: +61 - 3 - 9663 4453
Fax: +61 - 3 - 9667 7518
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