New Paper

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New Paper:

Graham, B. P., Van Ooyen, A. (2004) Transport limited effects in a model
of dendritic branching. J. Theor. Biol. 230: 421-432.

Abstract:

A variety of stochastic models of dendritic growth in developing neurons
have been formulated previously. Such models indicate that the
probability of a new branch forming in a growing tree may be modulated
by factors such as the number of terminals in the tree and their
centrifugal order. However, these models cannot identify any underlying
biophysical mechanisms that may cause such dependencies. Here we explore
a new model in which branching depends on the concentration of a
branch-determining substance in each terminal segment. The substance is
produced in the cell body and is transported by active transport and
diffusion to the terminals. The model reveals that transport-limited
effects may give rise to the same modulation of branching as indicated
by the stochastic models. Different limitations arise if transport is
dominated by active transport or by diffusion.

The full paper can be obtained in PDF from

http://www.anc.ed.ac.uk/~arjen/papers/Graham2004.html

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Arjen van Ooyen
Center for Neurogenomics and Cognitive Research
Vrije Universiteit, Amsterdam

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