From: sheryl_smith@netmail.hscbklyn.edu
Date: Mon Jan 29 2001 - 17:00:34 MST
Please post:
Postdoctoral position available:
Position available in cellular/molecular neuroscience lab to model
GABA-A receptor binding-gating relationships in response to modulators.
Concurrent neurophysiological experiments will assess rates of
deactivation and desensitization using rapid agonist application and
synaptic current recorded from the hippocampal slice. Modeling with
ScOP and Axograph will implement basic two and three state binding
models (Jones-Westbrook) as well as models of network oscillations.
Ongoing experiments in this laboratory (Nature 392: 926-930, 1998; J
Neuroscience 18: 5275-5284, 1998) have demonstrated that changes in
GABA receptor subunit composition may serve as compensatory mechanisms
to regulate neuronal excitability following prolonged exposure to
modulators. Such changes in excitability appear to be the result of a
faster deactivation rate, an effect which is dependent upon the rate of
ligand unbinding, channel open time and entry into or exit from
desensitized states. The use of appropriate models will facilitate our
understanding of the underlying mechanisms for such changes as well as
the impact of altered channel kinetics on macroscopic network
properties such as oscillation frequency.
Position available for 3-4 years; Annual salary: $40,000. Ph.D., M.D.
or equivalent required. If interested, please send CV and three letters
of reference to: Sheryl Smith, Ph.D., Dept. of Physiology and
Pharmacology, SUNY Health Science Center, 450 Clarkson Ave., Brooklyn,
NY 11203. email: Sheryl_smith@netmail.hscbklyn.edu; phone: 718-270-
2226, FAX: 718-270-3103.
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