[Comp-neuro] 2 papers on STDP and BCM rule

[Lubica Benuskova]

2 papers on the merged STDP and BCM rule are available online

 
1. Benuskova L and Abraham WC (2007) STDP rule endowed with the 
BCM sliding threshold accounts for hippocampal heterosynaptic
plasticity. 
Journal of Comp. Neurosci.  

http://www.springerlink.com/content/b51224m81192h232/?p=e62dc7092c3e485b9df83a6ba9ccff85&pi=5

 
2. Benuskova L and Kasabov N (2007) Modeling L-LTP based on changes in

concentration of pCREB transcription factor. Neurocomputing 
 http://dx.doi.org/10.1016/j.neucom.2006.10.133 
 

Abstract 1:  We have combined the nearest neighbour additive
spike-timing-dependent 
plasticity (STDP) rule with the Bienenstock, Cooper and Munro (BCM)
sliding modification 
threshold in a computational model of heterosynaptic plasticity in the
hippocampal 
dentate gyrus. As a result we can reproduce (1) homosynaptic long-term
potentiation 
of the tetanized input, and (2) heterosynaptic long-term depression of
the untetanized 
input, as observed in real experiments.

Abstract 2: We simulate the induction and maintenance of late long-term
potentiation 
(L-LTP) in the hippocampal dentate gyrus by means of a new synaptic
plasticity rule that 
is the result of combination of the spike-timing-dependent plasticity
(STDP) and the 
moving LTD/LTP threshold from the Bienenstock, Cooper and Munro (BCM)
theory 
of synaptic plasticity. We propose the activity-dependent functional
equation for 
moving LTD/LTP threshold to be based on two processes: (1) fast process
that depends 
on average postsynaptic spike count, and (2) slow process that is a
function of 
concentration of phosphorylated CREB (cAMP-responsive element binding)
transcription 
factor, activation of which induces gene expression to maintain L-LTP. 
In the end we 
propose a new, more general form of synaptic plasticity rule, which is
applicable to any 
form of activity-dependent synaptic plasticity.


Luba Benuskova, PhD
KEDRI, Auckland University of Technology
Auckland, New Zealand
http://www.ii.fmph.uniba.sk/~benus